Episodes (Page 4)
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Jeff Dean discusses shaping AI infrastructure from search to TPUs.
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Boltz is open-sourcing the future of drug discovery with new models.
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Goodfire converts mechanistic interpretability from 'peeking inside models' into production workflow via APIs and enterprise deployments, raising $150M Series B at $1.25B valuation
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Andrew White progresses from molecular dynamics simulations and red-teaming GPT-4 for chemistry to co-founding Future House (FRO) and Edison Scientific automating science at scale
Andrew White
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Yi Tay shipped Gemini Deep Think and IMO Gold, launched Reasoning and AGI team in Singapore expanding from 12 to 300+ researchers pivoting from architecture research to RL-driven reasoning
Yi Tay
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James Reggio led Brex's three-pillar AI strategy (corporate, operational, product AI) with SOP-driven agents outperforming overengineered RL in operations at scale
CTO James Reggio
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Artificial Analysis evolved from 2024 Sydney basement side project to independent gold standard for AI benchmarking trusted by developers, enterprises, and major labs
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LMArena raised $150M Series A at $1.7B valuation with $30M annualized consumption revenue ($2.5M MRR) after September 2025 evals product launch expansion
Anastasios Angelopoulos
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Kevin Wang et al. won NeurIPS 2025 Best Paper by scaling RL networks to 1,000 layers deep, defying decade-long conventional wisdom that depth fails in RL
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John Yang recaps SWE-bench's evolution from ignored (Oct 2023) to industry standard after Devin's launch, expanding from Django-heavy to 9 languages across 40 repos
John Yang
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Josh McGrath at OpenAI describes post-training evolution from 2023 PPO vs DPO debates to current RLVR era where data quality and signal trust matter more than optimization method
Josh McGrath
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Ashvin Nair from Cursor shipped RL breakthroughs on GPT-4o/o1/o3; reasoning team scaled from 12 to 300+ people; IOI Gold felt reachable in 2022 but only materialized when o1 shipped
Ashvin Nair
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Sarah Catanzaro transitions from modern data stack investing (DBT, Fivetran) to AI infrastructure frontier, warning that $100M+ seed rounds with no near-term roadmap are now standard
Sarah Catanzaro
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MCP evolved from local-only experiment (Thanksgiving launch) to de facto protocol adopted by OpenAI, Microsoft, Google, Block with hundreds of enterprise agents at scale
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Steve Yegge argues Claude Code, Cursor, and 2024 stack are obsolete, advocating for 'factory farming' era where developers manage fleets of AI agents instead of writing code
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Brian Fioca and Bill Chen from OpenAI's Codex and GPT-5 teams explain training agents to work 24+ hours, manage own context, and spawn sub-agents for parallel codebase work
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SAM 3 introduces concept segmentation
Joseph Nelson
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Pliny the Liberator and John V lead BT6
AI to AE's: Grit, Glean, and Kleiner Perkins' next Enterprise AI hit — Joubin Mirzadegan, Roadrunner
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Joubin Mirzadegan, now at Kleiner Perkins, is incubating Roadrunner, an AI-native rethink of CPQ and quoting workflows built for consumption-based pricing models
Joubin Mirzadegan
The Future of Email: Superhuman CTO on Your Inbox As the Real AI Agent (Not ChatGPT) — Loïc Houssier
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Loïc Houssier transitioned from applied cryptography and nuclear submarine optimization to CTO of Superhuman Mail, recently acquired by Grammarly