Notable Guests
LW
Lab Work
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Recent Episodes
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Explores three potential longevity 'vitamins' – taurine, ergothioneine, and PQQ – that may extend healthspan and promote longer life
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Dr. Brad Schoenfeld explains resistance training's role in body recomposition, including amplifying fat loss while preserving muscle
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Addresses skin barrier health and protection against photoaging through UV exposure reduction and hydrolyzed collagen supplementation
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Drs. Brad Schoenfeld and Stuart Phillips discuss minimum effective dose for muscle hypertrophy using time-efficient workout strategies
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Dr. Stuart Phillips explains sarcopenia – age-related muscle loss beginning in the 30s-40s – and its connection to longevity
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Examines NSAIDs (aspirin, ibuprofen, naproxen) mechanisms and their widespread use as both prescription and over-the-counter drugs
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Discusses dietary fiber's role in metabolic health and how gut microbes produce beneficial short-chain fatty acids from fiber breakdown
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Examines alcohol's contradictory effects – some research suggests health benefits while evidence shows increased cancer risk at higher intake
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Explains autoimmune disease pathogenesis when immune system mistakes body proteins for pathogens and discusses genetic and environmental dysfunction factors
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Dr. Bill Harris shares experience administering very high omega-3 doses (25+ grams) in human trials and their tolerability
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Discusses growth-longevity trade-off where fasting suppresses aging pathways (mTOR, IGF-1, growth hormone) while eating activates muscle growth
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Compiles recommendations from multiple FMF experts on blood tests and biomarkers to add to yearly checkups for health optimization
Lab Work
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Explains zinc's essential roles in immune function, protein synthesis, wound healing, DNA synthesis, and brain health
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Drs. Rhonda Patrick and Valter Longo describe fasting's role in restoring proper immune function and treating autoimmune disorders
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Dr. Roger Seheult explains interferon system's critical role in antiviral immunity and how its failures underpin up to 14% of severe COVID-19 cases
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Explains mRNA vaccine technology's advantages over traditional vaccines, including rapid development and modification capability for viral mutations
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Coffee consumption is associated with protection from chronic diseases including cancer, cardiovascular disease, and neurodegeneration via autophagy induction
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Explores IGF-1's dual nature as a growth factor essential for development and muscle growth yet implicated in aging and age-related diseases like cancer
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Drs. Satchin Panda and Ruth Patterson explain how time-restricted eating aligns food intake with circadian rhythms, enabling body repair over digestion
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APOE4 genetic variant is the strongest risk factor for Alzheimer's disease, affecting ~75 million Americans and linked to elevated LDL cholesterol