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AI Summary
- Four pillars of health—eat, sleep, move, connect—form the foundation of longevity; high protein and resistance training preserve muscle with age
- Fasting and time-restricted eating may not increase longevity; lifestyle factors like smoking, sedentary behavior, and obesity are primary lifespan reducers
- Emerging interventions like spermidine support autophagy; senescent cells drive chronic inflammation and age-related diseases