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AI Summary
- Ralph DeFronzo provides a comprehensive masterclass on insulin resistance pathophysiology and its full-body impacts across organs, drawing from five decades of groundbreaking research
- Detailed exploration of pharmacologic interventions including metformin, SGLT2 inhibitors, and GLP-1 receptor agonists, plus the gold-standard euglycemic clamp measurement method
- Insulin resistance is positioned as a foundational driver of chronic illness with practical prevention, diagnosis, and treatment strategies for type 2 diabetes management