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The Peter Attia Drive
The Peter Attia Drive

#359 ‒ How metabolic and immune system dysfunction drive the aging process, the role of NAD, promising interventions, aging clocks, and more | Eric Verdin, M.D.

Aug 4, 2025 · 02:11:11
AI Summary
  • Aging impairs immune and nervous system function including thymic shrinkage, chronic inflammation, reduced vaccine response linked to metabolic dysfunction and epigenetic changes
  • Metabolic underpinnings of aging include oxidative stress, insulin, and IGF-1 signaling; practical interventions include zone 2 cardio, ketogenic diets, and GLP-1 drugs
  • Declining NAD levels drive aging; NAD-consuming enzymes and metabolic interventions discussed; aging clocks and biomarkers address biological mechanisms of aging

Guests on This Episode

EV
Eric Verdin
2 podcast appearances

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