About This Episode
<p>The ancient fruit sitting in your grocery store right now outperforms rapamycin, rivals caloric restriction, and triggers a cellular cleanup process that most longevity scientists did not even know existed until a lab changed everything 18 years ago. </p><p> </p><p><br /></p><p>-Watch this episode on YouTube for the full video experience: <a href="https://www.youtube.com/@DaveAspreyBPR" rel="noopener noreferrer" target="_blank">https://www.youtube.com/@DaveAspreyBPR</a> </p><p>-Go to <a href="https://www.timeline.com/partners/dave-asprey" rel="noopener noreferrer" target="_blank">timeline.com/Dave</a> or just use code ‘Dave’ to get 20% off your next order. </p><p> </p><p><br /></p><p>Host Dave Asprey sits down with Chris Rinsch, co-founder and President of Timeline Longevity and a PhD cell biologist who has spent nearly two decades doing pharmaceutical quality clinical research on one of the most underrated longevity molecules on earth. Before founding Timeline in 2007, Rinsch worked in venture capital investing in pioneering life sciences companies and in biotechnology developing cell-based therapies at Swiss biotech company ISOTIS SA. He has authored original publications in Nature Medicine, Nature Metabolism, JAMA Open, and Cell Reports Medicine, and holds internationally filed and granted patents on urolithin A. This is the first time a Timeline co-founder has appeared on the show. </p><p> </p><p><br /></p><p>Together, Dave and Chris break down the full science of urolithin A, the postbiotic compound unlocked from pomegranate by gut bacteria, and why it triggers mitophagy to clear out damaged mitochondria and replace them with high-functioning ones. They cover why only 30 to 40 percent of people can produce urolithin A from food alone, how one month of supplementation measurably improved immune cell populations in people aged 50 to 70, and why Dave has stacked this into his daily longevity protocol alongside NAD precursors and nootropics for years. If you are serious about biohacking your mitochondria, extending healthspan, and doing smarter not harder longevity work, this episode delivers the deep science to back it up. </p><p> </p><p><br /></p><p>You'll Learn: </p><ul><li>Why urolithin A outperforms rapamycin in worm lifespan studies and rivals caloric restriction at 45 percent life extension </li><li>How mitophagy works, why it declines with age, and why it is one of the most important anti-aging mechanisms in the body </li><li>Why eating pomegranates or taking cheap pomegranate extract does not work for most people and what to take instead </li><li>How one month of MitoPure improved natural killer cells, CD8 T naive cells, and reduced inflammation in adults aged 50 to 70 </li><li>Why mitochondria are central to metabolism, brain optimization, immune function, cardiovascular health, and skin aging </li><li>How Timeline's topical urolithin A produced statistically significant reductions in fine lines and wrinkles after eight weeks </li><li>Why Dave considers this one of the most clinically validated supplements in his longevity stack alongside NAD and fasting protocols </li><li>How L'Oreal became a Timeline investor after confirming the mitochondrial science was unlike anything in their existing ingredient library </li><li>What the XPRIZE Healthspan competition is targeting and why Timeline is competing to reverse biological aging by 10 to 20 years </li><li>Why the future of functional medicine will require a mitochondrial blood test and how close we are to having one </li></ul><p> </p><p><br /></p><p><strong>Thank you to our sponsors!</strong> </p><p>- EMR-Tek | <a href="https://www.emr-tek.com/DAVE" rel="noopener noreferrer" target="_blank">https://www.emr-tek.com/DAVE</a> and use code DAVE </p><p>- Calroy | Go to <a href="http://calroy.com/DAVE" rel="noopener noreferrer" target="_blank">Calroy.com/DAVE</a> for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products. </p><p>- Neuronic | Go to <a href="http://www.neuronic.online/" rel="noopener noreferrer" target="_blank">www.neuronic.online</a> Code DAVE for $100 off </p><p>- ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to <a href="http://energybits.com/" rel="noopener noreferrer" target="_blank">ENERGYbits.com</a> and use code ASPREY for 20% off your order. </p><p><br /></p><p><br /></p><p><strong>Dave Asprey</strong> is a four-time New York Times bestselling author, founder of <strong>Bulletproof Coffee</strong>, and the <strong>father of biohacking</strong>. With over 1,000 interviews and 1 million monthly listeners, <em>The Human Upgrade</em> brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. </p><p> </p><p><br /></p><p>New episodes are released every <strong>Tuesday, Thursday, Friday, and Sunday (BONUS)</strong>. Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. </p><p> </p><p><br /></p><p><strong>Keywords: </strong>Chris Rinsch, Timeline Longevity, MitoPure, urolithin A, mitochondria, mitophagy, pomegranate, elagitannins, postbiotic, gut microbiome, longevity, anti-aging, healthspan, biohacking, supplements, human performance, metabolism, mitochondrial health, cellular health, autophagy, natural killer cells, immune health, inflammation, NAD, rapamycin, caloric restriction, muscle endurance, collagen, skin aging, fine lines, wrinkles, topical skincare, L'Oreal, XPRIZE Healthspan, Nature Aging, clinical trials, longevity stack, brain optimization, cardiovascular health, biological age, aging clock, fasting, nootropics, functional medicine, Dave Asprey, polyphenols, microbiome diversity </p><p> </p><p><br /></p><p><strong>Resources:</strong> </p><p>• Go to <a href="https://www.timeline.com/partners/dave-asprey" rel="noopener noreferrer" target="_blank">timeline.com/Dave</a> or just use code ‘Dave’ to get 20% off your next order. </p><p>• Get My 2026 Clean Nicotine Roadmap | Enroll for free at <a href="https://daveasprey.com/2026-clean-nicotine-roadmap/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/2026-clean-nicotine-roadmap/</a> </p><p>• Dave Asprey's Latest News | Go to <a href="https://daveasprey.com/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/</a> to join <em>Inside Track</em> today. </p><p>• Danger Coffee: <a href="https://dangercoffee.com/discount/dave15" rel="noopener noreferrer" target="_blank">https://dangercoffee.com/discount/dave15</a> </p><p>• My Daily Supplements: <a href="https://www.shopsuppgradelabs.com/discount/DAVE15" rel="noopener noreferrer" target="_blank">SuppGrade Labs</a> (15% Off) </p><p>• Favorite Blue Light Blocking Glasses: <a href="https://truedark.com/?coupon-code=DAVEASPREY15&sc-page=shop" rel="noopener noreferrer" target="_blank">TrueDark</a> (15% Off) </p><p>• Dave Asprey’s BEYOND Conference: <a href="https://beyondconference.com/" rel="noopener noreferrer" target="_blank">https://beyondconference.com</a> </p><p>• Dave Asprey’s New Book – <em>Heavily Meditated</em>: <a href="https://daveasprey.com/heavily-meditated" rel="noopener noreferrer" target="_blank">https://daveasprey.com/heavily-meditated</a> </p><p>• Join My Substack (Live Access To Podcast Recordings): <a href="https://substack.daveasprey.com/" rel="noopener noreferrer" target="_blank">https://substack.daveasprey.com/</a> </p><p>• Upgrade Labs: <a href="https://upgradelabs.com/" rel="noopener noreferrer" target="_blank">https://upgradelabs.com</a> </p><p> </p><p><br /></p><p><strong>Timestamps:</strong> </p><p>00:00 – Trailer </p><p>00:37 – Intro </p><p>03:57 – Pomegranates </p><p>10:03 – Discovering Urolithin A & Mitophagy </p><p>20:50 – Science vs. Pomegranate Supplements </p><p>25:24 – Topical Skincare Science </p><p>26:09 – L'Oreal Partnership & Skin Results </p><p>33:38 – 15 Clinical Studies & XPRIZE </p><p>43:50 – Nature Aging Immune Study </p><p>49:22 – Dosing & Daily Routine </p><p>51:29 – Future of Mitochondrial Health </p><p>See Privacy Policy at <a href="https://art19.com/privacy" rel="noopener noreferrer" target="_blank">https://art19.com/privacy</a> and California Privacy Notice at <a href="https://art19.com/privacy#do-not-sell-my-info" rel="noopener noreferrer" target="_blank">https://art19.com/privacy#do-not-sell-my-info</a>.</p>