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Y Combinator Startup Podcast

Y Combinator Startup Podcast

Y Combinator · Technology · EN-US

This podcast features Y Combinator partners and founders discussing the journey of building a startup, from initial idea to global scaling. Through real stories and practical advice, it offers insights into the challenges and successes of entrepreneurship. The show is geared towards aspiring and...

312
Episodes
94
Guests

Notable Guests

SS
Startup School 6x
OH
Office Hours 4x
Michael Seibel
Michael Seibel 4x
Tom Blomfield
Tom Blomfield 3x
MF
Main Function 3x
AE
Aaron Epstein 2x
Sam Altman
Sam Altman 2x
HT
Harj Taggar 2x
DB
Divya Bhat 2x
KH
Kevin Hale 2x
AC
Adora Cheung 2x
GR
Geoff Ralston 2x
CF
Camille Fournier 1x
CC
CEO of Convoy 1x
AH
Anu Hariharan 1x

Recent Episodes

May 13, 2026 · 00:21:57
Paul Graham discusses the unique value of Silicon Valley for ambitious founders.
Paul Graham
00:21:57
May 8, 2026 · 00:41:29
AI agents enable individuals to build complex products, previously needing large engineering teams.
00:41:29
May 1, 2026 · 00:37:52
Recursive AI models (HRMs, TRMs) achieve SOTA with fewer parameters.
00:37:52
Apr 29, 2026 · 00:40:56
Demis Hassabis, chess prodigy turned AI pioneer, founded DeepMind.
Demis Hassabis
00:40:56
Apr 25, 2026 · 00:39:11
Replit raised $400M at a $9B valuation for its no-code platform.
00:39:11
Apr 24, 2026 · 00:10:27
AI is the new operating system for companies, not just a productivity tool.
00:10:27
Apr 22, 2026 · 00:43:36
Stripe's Head of Design Katie Dill discusses their recent website redesign after six years.
Katie Dill
00:43:36
Apr 16, 2026 · 00:49:26
Physical Intelligence aims for a GPT-1 moment in robotics with a foundation model.
00:49:26
Apr 6, 2026 · 00:20:49
BillionToOne uses fetal DNA detection to create widely used prenatal tests.
00:20:49
Mar 31, 2026 · 00:31:23
Variance, a startup detecting fraud for Fortune 500s, raised $21 million Series A.
Karine Mellata
00:31:23
Mar 27, 2026 · 00:57:23
François Chollet explores building AGI from first principles, not just scaling.
00:57:23
Mar 20, 2026 · 00:13:07
Solugen combines biology and chemistry to reinvent chemical manufacturing.
00:13:07
Mar 16, 2026 · 00:39:32
Emergent's AI platform allows non-technical users to build production-ready software.
00:39:32
Mar 9, 2026 · 00:53:20
Max Hodak co-founded Neuralink and leads Science, focusing on BCIs.
00:53:20
Mar 6, 2026 · 00:37:26
Avoiding common pitfalls in no-code design tools.
Raphael Schaad
00:37:26
Feb 27, 2026 · 00:19:45
Poetiq uses recursive self-improvement for AI reasoning.
00:19:45
Feb 21, 2026 · 00:23:21
The AI agent economy is emerging with tools like OpenClaw.
00:23:21
Feb 17, 2026 · 00:50:10
Boris Cherny, creator of Claude Code, shares his journey.
Its Creator Boris Cherny
00:50:10
Feb 14, 2026 · 00:07:50
Startups win by automating internal functions, not just hiring faster.
00:07:50
Feb 7, 2026 · 00:22:35
Peter Steinberger created OpenClaw, a viral open-source AI assistant that runs locally and integrates with messaging apps to execute tasks like email, calendar, and workflow management
00:22:35

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